Edwin Willits (April 24, 1830 – October 22, 1896) was a politician from the U.S. State of Michigan.

Willits was principal of the Michigan State Normal School at Ypsilanti from 1883 to 1885. He served as president of the State Agricultural College from 1885 to 1889. In Grover Cleveland's first administration, he served as the first Assistant U.S. Secretary of Agriculture under Norman Jay Colman from March 23, 1889 to December 31, 1893.