The Lou Costello Comedy Room at Zissimos Bar in Hampden is located upstairs and offers stand-up comedy and improv performances.

This venue is named after the famous comedic actor Lou Costello, who was known for his connection to the bar and his family, who owned it. In the past, Costello visited the bar and engaged in various antics that have become part of its legacy.

The bar has been family-owned since 1930 and is known for being the oldest business in operation on the Avenue. Today, the upstairs of the bar has been renovated and now serves as a space for comedy nights