Update: In February, 2015, this mural was replaced by a mural by Stinkfishstink courtesy of LeQuiVive.
There's a mural by Chicago muralist Don't Fret on Webster between 15th and 17th downtown.
It portrays two people reaching to hold hands wrapped in a speech bubble that says "a burden" and "a time to reflect".
Don't Fret has also had a number of wheat pastes around town.